Ibaraki University's
Graduate School of Science and Engineering (Engineering)
Department of Materials Science and Engineering



Other affiliation / position

  1. Frontier Research Center for Applied Atomic Sciences


  1. 日本原子力研究所 先端基礎研究センター 博士研究員 1996/10-1999/09
  2. 日本原子力研究所 先端基礎研究センター 研究員 1999/10-2003/03
  3. 日本原子力研究所 中性子利用研究センター 研究員 2003/04-2004/04
  4. 茨城大学 工学部 助教授 2004/05-Present
  5. Professor 2011/04-Present

Academic background

  1. Tohoku University Graduate School, Division of Natural Science 物理学第2 Doctor course 1996 Completed

Academic degrees

  1. 博士(理学) Tohoku University

Current state of research and teaching activities

Neutron Stuctural Biology and Development of Related Technologiies

Research Areas

  1. Neutron Structural Biology

Research keywords

  1. neutron, structiral biology, hydrogen, protonation state, hydrated water, protein, nucleic acid, Japan Proton Accelerator Research Complex (J-PARC), neutron diffractometer, BIX, crystallography, Hydrogen and Hydration Database for biological macromolecules

Subject of research

  1. -Construction of a pulsed neutron diffractometer for bio-macromolecules in J-PARC funded by Ibaraki Prefecture 2004-2008
  2. -Structural biology on common proteins by neutron crystallography 2004-2009
  3. -Structural study of hydrogen bond involved in drug design and molecular recognition in bio-macromolecules with the help of HHDB 2005-2010
  4. -Quality evaluation of bio-macromolecules' single crystals 2004-2009
  5. -Crystallization phase diagram for large single crystals of bio-macromolecules 2004-2009


  1. The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery, (Ed. Makoto Suzuki) Ichiro Tanaka, Katsuhiro Kusaka, Nobuo Niimura Chap. 9 (Protonation/Deprotonation of Proteins by Neutron Diffraction Structure Analysis) Springer Singapore 2018/05/11 978-981-10-8458-4 URL
  2. Application of Neutron Diffraction in Studies of Protein Dynamics and Functions N. Niimura, M. Takimoto-Kamimura, I. Tanaka Encyclopedia of Analytical Chemistry, JohnWiley & Sons, Ltd. 2016/06/27
  3. 放射線を学ぼう!!! 菊地賢司、新村信雄、関東康祐、田中伸厚、車田亮、田中伊知朗、高橋東之 茨城大学特定課題震災対応-放射線教育と日立地区線量率計測班パンフレット作成グループ- 2011/11
  4. パルス中性子回折散乱実験入門 2009/03
  5. Hydrogen- and Hydration-Sensitive Structural Biology N. Niimura, S. Arai, K. Kurihara, T. Chatake, I. Tanaka and R. Bau Kuba Pro Co. Ltd., Tokyo, Japan 2005/07 4-87805-061-6


  1. Research paper (scientific journal) Joint Preliminary results of neutron structural analysis of glucose isomerase under natural conditions during an enzyme reaction S. Yamoto, N. Komatsuzaki, K. Kusaka, N. Yano, N. Okuda, Akio Sasaki, I. Tanaka Physica B Elsevier 2018 10.1016/j.physb.2018.01.048
  2. Research paper (bulletin of university, research institution) Joint Preparation of Sugar-Lysozyme Complexes for Neutron Structure Analysis 後藤亮祐,日下勝弘,矢野直峰,田中伊知朗 Photon Factory Activity Report 2016 #34 268-268 2017/07
  3. Research paper (bulletin of university, research institution) Joint Generalization of High-Pressure Freezing Method of Proteins 杉山玲, 田中伊知朗 Photon Factory Activity Report 2016 #34 266-266 2017/07
  4. Research paper (scientific journal) Joint Application of profile fitting method to neutron time-of-flight protein single crystal diffraction data collected at the iBIX Naomine Yano, Taro Yamada, Takaaki Hosoya, Takashi Ohhara, Ichiro Tanaka & Katsuhiro Kusaka Scientific Reports Nature Publishing Group, Macmillan Publishers Limited, part of Springer Nature 6/ 36628, 1-9 2016/12/01 10.1038/srep36628 タンパク質単結晶のパルス中性子回折において、回折斑点強度をより高精度に決定するプロファイルフィッティング法を実用化することに成功した。
  5. Research paper (scientific journal) Joint 中性子/X線結晶構造解析によって明らかとなった反転型セルロース加水分解酵素のプロトン伝達経路を含んだ反応機構 中村彰彦、石田卓也、日下勝弘、田中伊知朗、新村信雄、鮫島正浩、五十嵐圭日子 日本中性子科学会誌「波紋」 26/ 3, 139-142 2016/10

Research presentations

  1. Oral presentation(invited, special) 新型生体高分子回折計(iBIX)の概要と化学・生命科学にもたらす新展開 Annual Meeting of the Crystallographic Society of Japan 2006/12
  2. Oral presentation(invited, special) IBARAKI Biological Crystal Diffractometer in J-PARC (BIX-P1)-General View- American Crystallographic Society Annual Meeting 2006/06
  3. Oral presentation(invited, special) Initial Neutron Protein Diffraction Results at iBIX in J-PARC International Conference on Neutron Scattering 2009(ICNS2009) 2009/05/05
  4. Oral presentation(invited, special) Neutron protein crystallography in JRR-3 and future prospect in J-PARC 2nd International Symposium on Diffraction Structural Biology (ISDSB 2007) 2007/07
  5. Oral presentation(invited, special) Future Prospect of Neutron Protein Crystallography by Using New Spallation Neutron Sources International Workshop on Advanced Jaue Diffraction in Frontier Science (Laue 2007) 2007/01

Intellectual property rights

  1. 放射線画像読取装置 特願2001-127394 2001/04/25 特開2002-323726 2002/11/08


  1. 波紋President Choice 中性子/X線結晶構造解析によって明らかとなった反転型セルロース加水分解酵素のプロトン伝達経路を含んだ反応機構 2016/12/01

Alloted class

  1. 応用機能化学実験I/生命電子情報実験I
  2. 生体分子構造学
  3. 生体分子機能特別研究I
  4. 生体分子機能特別研究III
  5. J-PARC演習

Memberships of academic societies

  1. 日本中性子科学会
  2. 日本結晶学会
  3. 日本生物物理学会
  4. 日本生化学会

Committee Career

  1. 日本中性子科学会 第14回中性子科学会賞選考委員会委員長 2016/06/01-2017/03/31