Ibaraki University's
Graduate School of Science and Engineering

Professor

UNNO Masaki


Career

  1. JSPS Research Fellowship (DC1) 1998/04/01-2001/03/31
  2. Research Associate of Institute of Multidisciplinary Research for Advanced Materials, Tohoku University 2002/04/01-2007/03/31
  3. Assistant Professor of Institute of Multidisciplinary Research for Advanced Materials, Tohoku University 2007/04/01-2009/04/30
  4. Associate Professor of Frontier Research Center for Applied Atomic Sciences, Ibaraki University 2009/05/01-2013/03/31
  5. Professor, Graduate School of Science and Engineering, Ibarali University 2013/04/01-Present

Academic background

  1. Osaka University Faculty of Science Macromolecules 1996/03 Graduated
  2. Osaka University Graduate School, Division of Natural Science Macromolecular Science Master course 1998/03 Completed
  3. Osaka University Graduate School, Division of Natural Science Macromolecular Science Doctor later 2002/03 Completed

Academic degrees

  1. Ph. D. Osaka University 2002/03

Current state of research and teaching activities

Structure-Function Relationships of Biological Macromolecules Based on Structural Analysis at Atomic Level

Research Areas

  1. Chemistry Related to Living Body
  2. Structural Biochemistry

Research keywords

  1. Protein, Structure, Function, X-ray crystallography, Atomic level, Reaction mechanism, Drug design, Intermediate

Subject of research

  1. Structural Analyses of Biological Macromolecules at Atomic Level In order to elucidate the misteries of life, We will determine the structures of biological macromolecules and discuss the their structre-function relationships at atomic level.

Proposed theme of joint or funded research

  1. Analyses of Structures and Fuctions of Proteins (キーワード) X-ray Crystallography Joint research with other research organizations such as universities. Joint research 重要なまたはユニークな蛋白質の機能を研究している方と共同研究をしたいです。その構造を原子レベルで明らかにすることで、その蛋白質の持っている機能との相関について明らかにしていきたいと思っています。

Bibliography

  1. Structures and Functions of Peptidylarginine Deiminases (Protein Deimination in Human Health and Disease 2) Unno, M., Kizawa, K., Takahara, H. Springer 2017/10 978-3-319-58244-3 URL
  2. Nanohybridazation of Organic-Inorganic Materials Masaki UNNO, Masao Ikeda-Saito Springer 2009/11/30
  3. 放射光科学入門 海野昌喜, 齋藤正男 東北大学出版会 2004/03/31 ISBN4-925085-83-2
  4. Integrating Approach to Photofunctional Hybrid Materials for Energy and the Environment Masaki UNNO, Masakazu SUGISHIMA, Kei WADA, Keiichi FUKUYAMA Nova Publishers 2013 978-1-62417-638-8
  5. Protein Deimination in Human Health and Disease Kenji Kizawa, Masaki Unno, Claus W. Heizmann, Hidenari Takahara Springer 2014 978-1-4614-8317-5

Papers

  1. Research paper (scientific journal) Joint The Structure of the Mammalian 20S Proteasome at 2.75 Å Resolution Masaki Unno, Tsunehiro Mizushima, Yukio Morimoto, Yoshikazu Tomisugi, Keiji Tanaka, Noritake Yasuoka Tomitake Tsukihara Structure 10/ 5, 609-618 2002 10.1016/S0969-2126(02)00748-7
  2. Research paper (scientific journal) Joint Insights into the Proton Transfer Mechanism of a Bilin Reductase PcyA Following Neutron Crystallography Masaki Unno, Kumiko Ishikawa-Suto, Katsuhiro Kusaka, Taro Tamada, Yoshinori Hagiwara, Masakazu Sugishima, Kei Wada, Taro Yamada, Katsuaki Tomoyori, Takaaki Hosoya, Ichiro Tanaka, Nobuo Niimura, Ryota Kuroki, Koji Inaka, Makiko Ishihara, and Keiichi Fukuyama J. Am. Chem. Soc. 137/ 16, 5452–5460 2015/04/15 10.1021/jacs.5b00645
  3. Research paper (scientific journal) Joint Crystal Structure of the Dioxygen-bound Heme Oxygenase from Corynebacterium diphtheriae Masaki Unno, Toshitaka Matsui, Grace C. Chu, Manon Couture, Tadashi Yoshida, Denis L. Rousseau, John. S. Olson, and Masao Ikeda-Saito J. Biol. Chem. 279/ 20 2004 10.1074/jbc.M400491200
  4. Research paper (scientific journal) Joint Monomeric Form of Peptidylarginine Deiminase Type I Revealed by X-ray Crystallography and Small-Angle X-ray Scattering Shinya Saijo, Anna Nagai, Saya Kinjo, Ryutaro Mashimo, Megumi Akimoto, Kenji Kizawa, Toshiki Yabe-Wada, Nobutaka Shimizu, Hidenari Takahara, Masaki Unno J. Mol. Biol. 428/ 15, 3058-3073 2016/07/31 10.1016/j.jmb.2016.06.018
  5. Research paper (scientific journal) Joint Structures of the Substrate-free and Product-bound Forms of HmuO, a Heme Oxygenase from Corynebacterium diphtheriae: X-RAY CRYSTALLOGRAPHY AND MOLECULAR DYNAMICS INVESTIGATION. Unno, M., Ardèvol, A., Rovira, C., Ikeda-Saito, M. J. Biol. Chem. 288/ 48, 34443-34458 2013/11/29 10.1074/jbc.M113.486936

Research presentations

  1. Oral presentation(general) The studies for X-ray crystallographic analysis of the Ca2+ and Zn2+ bound human S100A3 protein tetramer 生物物理学会 第55回年会 2017/09/19 URL
  2. Poster presentation Structural QM/MM Investigation of Bilin Reductase PcyA-substrate Complex. 第11回 分子科学討論会 2017/09/16 URL
  3. Oral presentation(invited, special) 中性子構造解析を中心とした手法で解明する光合成色素フィコシアノビリンの合成メカニズム 平成29年度iBIX-JAXA合同タンパク質研究会 2017/08/04 URL
  4. Poster presentation X線結晶構造解析とX線小角散乱による蛋白質脱イミノ化酵素PAD1の構造 第16回 東北大学多元物質科学研究所研究発表会 2016/12/07
  5. Oral presentation(general) Structural Studies of Peptidylarginine Deiminase Type I using X-ray Crystallography and Small-angle X-ray Scattering 14th Conference of Asian Crystallographic Association 2016/12/06

Prizes

  1. 多元研究奨励賞 2007/11
  2. 日本生物物理学会若手奨励賞 2005/11/24

Alloted class

  1. 大学入門ゼミ
  2. 生体高分子特論
  3. 放射線計測実習
  4. 生体分子機能基礎化学実験
  5. 生体分子機能応用化学実験

Memberships of academic societies

  1. The Biophysical Society of Japan 2005/05-Present
  2. The Japanese Biochemical Society 2002/05-Present
  3. Protein Science Society of Japan 2001/10-Present
  4. The Crystallography Society of Japan 1995/10-Present

Committee Career

  1. 日本蛋白質科学会 選挙管理委員 2017/06/21-2019/06
  2. 日本蛋白質科学会 代議員 2017/06/21-2019/06
  3. 日本生物物理学会 代議員 2017/04/01-2019/03/31
  4. 日本結晶学会 広報委員 2016/04/01-2018/03/31
  5. 日本結晶学会 行事委員 2016/04/01-2018/03/31